N-terminal protein sequencing
Our protein sequencing service, accredited by UKAS to ISO 17025:2017, helps determine the exact amino acid sequence of your purified peptide or protein.
Otherwise known as Edman degradation, this technique is known for its high reliability, robustness and accuracy in providing an unambiguous amino acid sequence read that can be used for peptide or protein identification and characterisation.
We offer the following protein sequencing services to customers worldwide from our ISO 9001-certified laboratory. Our N-terminal protein sequencing service is also accredited to ISO/IEC 17025:2017.
Information on preparing and sending samples for N-terminal sequencing can be found on our protein sequencing sample information page.
Protein sequencing applications
Protein sequencing is an important tool for many scientific areas, such as drug development, biotechnology, and biochemistry. By providing insights into the structure, function, and interactions of proteins, protein sequencing plays a critical role in advancing our understanding of biological processes and in the development of new therapies and treatments. Protein characterisation services are routinely used for the following applications:
- To confirm the amino acid sequence of proteins, peptides and antibodies
- To identify and characterise proteins and peptides by comparing the obtained sequence with sequences in protein databases.
- To identify protein truncation sites and better understand the protein degradation mechanisms
- To determine the presence and location of post-translational modifications
- For quality control to confirm the correct translation of a recombinant protein
- For identification of potential drug targets by studying the characteristics and function of specific proteins
- To understand the structure and function of specific proteins, which is essential for drug design and many other applications.
- For identification of mutations and variants in proteins, which can provide insights into disease susceptibility and pathogenesis.
- For the study of evolutionary relationships among species, by comparing the amino acid sequences of homologous proteins.
- To ensure the quality and purity of biopharmaceuticals, such as monoclonal antibodies and recombinant proteins.
- For the study of protein-protein interactions, which are critical for understanding many cellular processes.
- As a fundamental tool in proteomics, the large-scale study of proteins and their functions.
- For identification of biomarkers, which are specific proteins or protein patterns that can indicate the presence of a disease or a response to a treatment.
Frequently asked questions
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